Our companies solve hard but not impossible problems.
3
Funds raised
$50M
Current fund
$1-2M
Typical check
10%
Target ownership
Our Portfolio
Discover the companies shaping the future with Refactor.
Climate
FYTO is building sustainable, novel nutrient-dense crops.
Phytoform edits the genomes of crops to activate novel traits.
Berkeley Yeast engineers brewer’s yeast to do incredible things.
Mori extends the shelf life of perishable foods using silk protein.
Solugen uses biology to build chemicals.
Checkerspot builds sustainable, algae-based physical materials.
Floodbase is a global parametric flood insurance solution.
Pomodyne is revolutionizing the cultivation of fruit crops.
Macro Oceans transforms seaweed into low-carbon chemicals.
Thalo measures and mitigates greenhouse gas emissions in the built environment.
Hyfé transforms wastewater into valuable products.
Reel is creating 100% cell-based seafood.
Lumindt is building solid-state hydrogen batteries.
Intropic is creating truly compostable and self-degrading products.
Biology
Biorender is redefining how science is communicated.
Spring is a computational biology company focused on aging.
Verge uses ML and genomics to tackle neurodegenerative diseases.
Culture is building the future of biomanufacturing.
64x is transforming the future of cell and gene therapy manufacturing.
Aether is a computational enzyme discovery platform.
Juvena develops therapeutics for tissue regeneration.
Curative is scaling COVID-19 detection and vaccination.
Kin has created a whole new category of beverages called euphorics.
Biobot measures opioids and COVID-19 in sewer water.
Rubedo is an anti-aging company hoping to extend health-span.
Gencove's low-pass sequencing is the most efficient for genomic discovery.
Shape is a next-gen RNA-targeting gene therapy company.
Orchid helps couples have the healthiest children possible.
Loyal is giving our best friends (our dogs) more time with us.
Redesign uses physics-based modeling for drug discovery.
Octant is building a novel drug discovery platform.
Mythic is building smarter and safer anti-drug conjugates.
YourChoice is developing the pill for men.
Miist develops orally inhaled therapeutics.
Health
Hero helps manage medications end to end.
PathAI is advancing medicine with intelligent pathology.
Brave Care is re-inventing pediatrics, starting with urgent care.
Headspace teaches millions in 200+ countries how to live mindfully.
Picnic structures the world's medical data and makes it useful.
Lucy’s aim is to eliminate smoking via effective nicotine products.
Ophelia provides medication & support for quitting opioids.
Vital is modern emergency department software.
AKASA is modernizing revenue cycle operations for healthcare.
Evernow provides custom menopause treatment plans.
Spora is the culture-centered healthcare provider.
And...
LTSE is building a new exchange to realign investors and companies.
Legalist is an algorithmic litigation financing solution.
Knowde enables chemical producers to market their products to buyers.
Bulk MRO is a one-stop shop for industrial products in India.
Alloy is software for teams that make, move, and sell products.
Astranis is building the next generation of telecom satellites.
Red Leader is building a software-based LIDAR system.
Mosaic creates plant-powered, healthy meals by the bowl.
Magic is transforming the antiquated user identity space.
Reserve is building a stable, decentralized currency.
Playground helps you create stunning images and art.
Graduates
Coinbase is a cryptocurrency exchange and went public ($COIN).
Able helps providers get paid and was acquired by Health Catalyst ($HCAT).
ANA is fighting COVID and was acquired by Neurobo ($NRBO).
Blockfolio is a crypto wallet and was acquired by FTX.
Umbrella is a senior care marketplace and was acquired ($IAC).
Betty Labs built Locker Room and was acquired by Spotify ($SPOT).
Clover is a Medicare Advantage company and went public ($CLOV).
Kip is a mental health company and was acquired by Modern Health.
Hero is a CRM app and was acquired by People.AI.
FactoryFour builds automation software and was acquired by Xometry ($XMTR).
Tempest is a digital recovery program and was acquired by Monument.
Enzyme is FDA compliance as a service and was acquired by Roivant ($ROIV).
Uniform is a tele-health orthodontics company and was acquired by Impress Dental.
Avail provides virtual surgery consults and was acquired by Mendaera.